己酮可可碱对慢性阻塞性肺疾病患者血凝状态血液流变学的影响

彭石龙吴湘兰邵卫华.中华临床新医学,2005，5(8)：686-687

    摘要 目的 探索己酮可可碱（pentoxifylline，PTX）吸入治疗对慢性阻塞性肺疾病（COPD）患者血凝状态和血液流变学的影响。方法 41例COPD患者，随机单盲分成两组：治疗组21例，PTX 100mg加入生理盐水5ml经超声雾化吸入；对照组20例，糜蛋白酶5mg加生理盐水5ml雾化吸入。两组均2次／d，疗程2周。治疗前后常规检查肺功能（FEV1）、动脉血气、肝。肾功能、血凝和血液流变学指标等。结果治疗组治疗后PCV、D-二聚体、血浆黏度下降有显著性差异（P＜0.05），全血黏度（高切和低切）下降有极显著差异（P＜0.01）；PaCO2下降（P＜0.01），PaO2及SaO2%增高（P＜0.01）；血肌酐降低（P＜0.05）；对照组各指标均无变化（P〉0．05）。两组治疗前后肝功能及尿素氮无统计学差异（P〉0．05）。结论 本实验表明：PTX吸入治疗对改善COPD高凝状态和血液流变学具有较好的疗效。

The effects of Pentoxifylline on the blood Coagulable Status and Hemorheology in Patients with Chronic Obstructive Pulmonary Disease

Abstract:

Objective To study the effects of inhaled Pentoxiflline（FIX） on the blood coagulable status and hemorheology in patients with chronic obstructive pulmonary disease（COPD）. Methods 41 cases were randomly divided into two groups by single blind. Treatment group： 21 cases, FIX 100mg in 5 ml normal saline. Control group： 20 cases, chymotrypsin 5mg in 5ml normal saline. All cases were inhaled by ultrasonic nebulization, b.i.d, for 2 wk. Before and after treat, pulmonary function （ FEV1 ）, arterial blood gas analysis, parameters of blood coagulability and hemorheology were examined in all case. Results After treament, PCV, D - Dimer, blood viscosity and coagulable parameters were significantly decreased （P 〈 0.05 or P〈 0.01 ）. With the improvement of the above parameters, PaCO2 decreased too （P 〈 0.01 ）, PaO2 and SaO2 % increaseed （P〈0.01）. There are no significant changes in the control group. Conclusion Pentoxifylline inhaletion has good effects on hypecogulable status and hemorheology in patients with chronic obstructive pulmonary disease.