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(2007-11-12 06:29:42)
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健康/保健pdautophagy |
分类： 自噬 |
今天把这篇文章找出来，推荐给大家，对有兴趣在PD
and Autophagy领域的朋友，值得一睹为快！
Autophagy.[Miscellaneous
Article]
Department of Laboratory Medicine and
Pathology, University of Minnesota, Minneapolis, Minnesota 55455,
USA
Annals of the New York Academy of Sciences.
1066:259-271, 2005.
Autophagy is a major intracellular pathway for the
degradation and recycling of long-lived proteins and cytoplasmic
organelles. Like apoptotic programmed cell death,
autophagy is an essential part of growth regulation and
maintenance of homeostasis in multicellular organisms. Autophagic
vacuole formation is also activated as an adaptive response to a
variety of extracellular and intracellular stimuli, including
nutrient deprivation, hormonal or therapeutic treatment, bacterial
infection, aggregated and misfolded proteins and damaged
organelles. Mediators of class I and class III PI3 kinase signaling
pathways and trimeric G proteins play major roles in regulating
autophagosome formation during the stress response.
Defective autophagy is the underlying cause of a number of
pathological conditions, including vacuolar myopathies,
neurodegenerative diseases, liver disease, and some forms of
cancer. This chapter provides an overview of the morphology and
molecular basis of autophagosome formation and offers a glimpse
into the role of autophagy in normal growth and development, while discussing
the pathological implications of its
deregulation.
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