加载中…Parkinson’s disease (PD) is a chronic disease with progressive disability
(2010-11-15 06:28:26)
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autophagypdα-syn自噬生命科学杂谈 |
分类： 帕金森病 |
Abstract
Parkinson’s disease (PD) is
a chronic disease with progressive disability. It has been
typically categorised in early and advanced stage according to the
severity of motor symptoms, the overall benefit from
antiparkinsonian drugs, and the emergence of drug-induced motor
complications. Data on the clinical characteristics of the more
advanced disease stages are more limited. Patient cohorts with more
than 10 years disease duration have presented a high frequency of
non-motor symptoms like sleep disorders, autonomic failure and
dementia. However, a recent study on late-stage PD patients has
questioned the inevitability of dementia. In late-stage PD,
non-motor symptoms may dominate the clinical picture and have a
significant impact on disability, appearing as the strongest
independent predictors of nursing home placement. Very advanced PD
patients will represent an important burden for families and the
healthcare system.A prerequisite for the development of effective
interventions (pharmacological and nonpharmacological) for these
most advanced stages is the better characterization of its
phenomenology. Social interventions should be included in the list
of potential therapeutic interventions for which there is a need to
produce robust data on effectiveness.
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