加载中…MerTK-巨噬细胞的界定标准
(2016-08-24 14:03:39)
标签：
mertk巨噬细胞凋亡细胞清除炎症修复组织稳态 |
分类： eBioscience |
凋亡细胞的清除对组织稳态和炎症的修复很关键。MerTK是巨噬细胞表面的一类蛋白质，它能够调节炎症修复，效应细胞增生。通过与凋亡细胞表面翻转的磷酯酰丝氨酸结合，能够发生吞噬作用。此外，巨噬细胞还能够抑制NF-KB信号通路。有研究表明，MerTK信号能够促进SPM(炎症损伤修复过程依赖于特定的调节因子)的合成。MerTK 在静息巨噬细胞中及免疫抑制期间是作为一种耐受性受体。它属于酪氨酸激酶受体中的TAM家族，在组织巨噬细胞中表达。因此，MerTK和CD64的双重表达正成为巨噬细胞的界定标准，并帮助将组织巨噬细胞从树突状细胞中区分出来。
MerTK能调节巨噬细胞活化，促进凋亡细胞的吞噬，帮助血小板聚集，并维持体内血块的稳定。MerTK在多种类型的癌症中会发生过表达或异位表达，如白血病、非小细胞肺癌、黑色素瘤和前列腺癌等，这可能会导致若干典型的致癌信号传导途径的活化。
| http://liankebio.com/public/images/50/f2/59/5a2866efd7b07320f5c3b631df9cb15b55a90743.jpg?1472007720#h | |
Human monocyte-derived macrophages
cultured in the presence of Human M-CSF Recombinant Protein (cat.
14-8789) and dexamethazone were stained with Anti-Human CD11b APC
(cat. 17-0118) and Mouse IgG1 K Isotype Control PE (cat. 12-4714)
(left) or Anti-Human MerTK PE (right). Total viable cells, as
determined by Fixable Viability Dye eFluor® 450 (cat. 65-0863),
were used for analysis. |
相关产品：
| 品牌 | 产品货号 | 产品名称 | 规格 | 目录价 |
| eBioscience | 85-12-9043-41 | Anti-Human Mer PE 25 tests | 25 tests | 1287 |
| eBioscience | 85-12-9043-42 | Anti-Human Mer PE 100 tests | 100 tests | 3627 |
| eBioscience | 85-12-5751-80 | Anti-Mouse MerTK PE | 25 ug | 1157 |
| eBioscience | 85-12-5751-82 | Anti-Mouse MerTK PE | 100 ug | 3237 |
| eBioscience | 85-14-5751-80 | Anti-Mouse MerTK Purified | 25 ug | 1287 |
| eBioscience | 85-14-5751-82 | Anti-Mouse MerTK Purified | 100 ug | 3627 |
| eBioscience | 85-25-5751-80 | Anti-Mouse MerTK PE-Cyanine7 | 25 ug | 1807 |
| eBioscience | 85-25-5751-82 | Anti-Mouse MerTK PE-Cyanine7 | 100 ug | 4407 |
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