2014年11月07日
(2014-11-07 03:39:45)Can A Fecal Transplant Cure IBD, Colitis, Crohn's, C. difficile, Multiple Sclerosis..?
Some
call it a fecal transplantation. Others, fecal bacteriotherapy.
Call it what you want, but there is regenerative power in poop for
severe, bowel problems. Seriously? Yes. Cure rates are generally
above 90% for Clostridium difficile; treatments for Crohn's
Disease and Multiple Sclerosis are not as well studied, but appear
promising. Everyone should know about fecal transplants as C.
difficile infections have risen 400% since 2000 (largely due to
hospitals spreading them). Just in the past year, I have had one
family member and one friend come down with C. diff
infection. Doctors are recalcitrant to prescribe fecal transplants,
but that appears to be due to lack of knowledge rather than
success.
- CNN raised the profile of fecal transplants a trillion fold
when it posted this article on the front page of its website a
couple of days ago:
Little known fecal transplant cures woman's bacterial infection. If anyone was previously skeptical, this article basically legitimizes fecal transplantation. - The Henry Ford Hospital in Detroit, MI recently found that
43/49 patients with C. difficile infections were cured after
fecal transplants; they had no problems up to three months
later.
Fecal transplant from mom cures ailing toddler. - A 2011 literature review found that 92% of 317 patients with
recurrent C. difficile infection or pseudomembranous colitis
had disease resolution upon fecal
transplant.
- Clinics and retreats are offered! For instance in the US, the Bright Medicine Clinic in Portland, Oregon performs Fecal Transplants for many conditions discussed below.
- There's a blog called Fecal Microbiota Transplant that reports seemingly unpublished data on transplants improving Multiple Sclerosis in patients with bowel syndromes. At a minimum, patients were able to walk again!
- Two papers on inflammatory bowel disease indicate that of nine
patients who were non-responsive to standard treatment, all nine of
them responded dramatically well to fecal transplant therapy.
Bacteriotherapy Using Fecal Flora (2004) and Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy (2003) - We NEED a site that provides location information on fecal
transplants. I can not seem to find one and people will clearly
be asking for more information. Googling around appears to come up
with specific instances, so if you search hard enough, you may find
something in your neck of the woods. (There is a partial list of USA fecal transplant
places here);
if you're in TN, Vanderbilt's clinical chief, Dr. Michael Vaezi of Gastroenterology is doing fecal transplants in response to refractory Clostridium difficult; In Virginia at the Virginia Commonwealth University, Dr. Michael Edmond is doing fecal transplants for C. diff [news link]; In Nevada, Gastroenterology Consultants in Carson City offers fecal transplantation for C. diff - There's a Facebook Page that appears to be a good social media resource, aptly named Fecal Bacteriotherapy is "The Bomb"
- There are reports on the internet of do-it-yourself fecal
transplants. Clinics can be hard to find and the treatment is not
typically covered under insurance, especially for IBD.
Understandably, these barriers to a treatment have led some to
pursue self-treatment with enema kits. Probiotic Therapy Home
Infusion Protocol and Success of Self-Administered
Home Fecal Transplantation for C. difficile
Infection.
- A University of Guelph lab in Canada has developed a Robogut machine to simulate the human gut conditions in vitro. They have successfully used it to grow a cocktail of bacteria that cured C. diff infections from two elderly patients. What a breakthrough! Symbionticism Blog Post Link
Background: Despite the conventional lexicon that poop
is dirty, an agent of infection, and should be left for one place
and one place only - the toilet, poop may be as powerful in its
regenerative capacity as stem cells. Perhaps better. Roughly 40% of
your feces is made up of bacteria living inside and shed from your
gut. These species help us digest food, develop intestinal tissue,
and fight off infections among many other things.
Disease: The bacteria in your gut are as much a part of you as your genes. The fact that some fraction of them come out in your waste is fortunate because these symbiotic bacteria can be used in the purest form of recycling that humans may ever know. Friends or family that are suffering month-to-month, or year-to-year, with debilitating or deadly diseases such as Crohn's disease, ulcerative colitis(these first two are often
referred to as IBD or inflammatory bowel
disease), Clostridium
difficile, etc know all too well the long and
painful aspects of these diseases. In many cases,
antibiotics are prescribed over and over, with each one that fails
leading to more expensive ones that are also more difficult to get.
The irony of the antibiotic ferris wheel is that antibiotics may be
buying a little more time or even exacerbating the problem, while
the solution happens to be right in front of us, or behind us to be
technically accurate. The healthy bacteria in poop from a friend or
family member can be "transplanted" into the gut of a sick patient
and fully cure them in many cases.
Professor Thomas Borody(MD, PhD) is one of the leading
physician scientists in this area and this video is definitely
worth watching and sharing to classrooms, friends, and
family.
Disease: The bacteria in your gut are as much a part of you as your genes. The fact that some fraction of them come out in your waste is fortunate because these symbiotic bacteria can be used in the purest form of recycling that humans may ever know. Friends or family that are suffering month-to-month, or year-to-year, with debilitating or deadly diseases such as Crohn's disease, ulcerative colitis
Professor Thomas Borody
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