Honored Speaker Lecture
David Naylor, MD
University of Toronto

General Thoracic Surgery Forum
Constitution 106, Metro Toronto Convention Centre

F11. Vascular Endothelium Contributes to Tumor Tolerance Induction
Ruben G. Nava, Sanjay Murala, Alec Patterson, Andrew Gelman, Daniel Kreisel, Sasha A. Krupnick;
Surgery, Washington University in St Louis, St Louis, MO, USA.

Invited Discussant: David R. Jones, MD

F12. Gene Expression Profiles in Esophageal Adenocarcinoma Predict Survival Following Resection
Arjun Pennathur¹, Liqiang Xi³, Virginia R. Litle², William E. Gooding¹, Rodney J. Landreneau¹, Tony Godfrey², James D. Luketich¹
1. The Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2. University of Rochester Medical Center, Rochester, NY; 3. National Cancer Institute, Rockville, MD, USA.

Invited Discussant: Chuong D. Hoang, MD

F13. Optimized Intrapleural Cisplatin Chemotherapy with a Fibrin Carrier After Extrapleural Pneumonectomy -  A Pre-Clinical Study
Isabelle Opitz¹, Barbara V. Erne¹, Seval Demirbas¹, Alexander Jetter², Burkhardt Seifert⁴, Rolf Stahel³, Walter Weder¹
1. Division of Thoracic Surgery, University Hopsital, Zurich, Switzerland; 2. Institute for Pharmacology and Toxicology, University Hospital, Zurich, Switzerland; 3. Department of Oncology, University Hospital, Zurich, Switzerland; 4. Institute for Biostatistics, University, Zurich, Switzerland.

Invited Discussant: W. Roy  Smythe, MD

F14. Deletion of Tissue Plasminogen Activator Prevents Lung Ischemia-Reperfusion Injury via Inhibition of Neutrophil Extravasation
Yunge Zhao, Abbas Emaminia, Ashish K. Sharma, John Steidle, Gorav Ailawadi, Irving L. Kron, Christine L. Lau
Surgery, University of Virginia, Charlottesville, VA, USA.

Invited Discussant: Marc de Perrot, MD

F15. The Chemokine/Chemokine Receptor Pair, CXCL12/CXCR4 is a Key Pathway in Lung Adenocarcinoma Tumor Cells Tumor Associated Fibroblasts Crosstalk
Ori Wald¹, Uzi Izhar¹, Gail Amir⁴, Sophie Kirshberg², Zippora Shlomai³, Amnon Peled², Oz M. Shapira¹
1. Cardiothoracic Surgery, Hadassah University Hospital, Jerusalem, Israel; 2. Goldyne Savad Gene Therapy Institute, Hadassah University Hospital, Jerusalem, Israel; 3. Laboratory for Surgical Research, Hadassah University Hospital, Jerusalem, Israel; 4. Pathology, Hadassah University Hospital, Jerusalem, Israel.

Invited Discussant: Steven J. Mentzer, MD

F16. WNT Pathway Activation Predicts Increased Risk of Tumor Recurrence in Patients with Stage I Non-Small Cell Lung Cancer
Mark Shapiro¹, Gal Akiri³, Cynthia S. Chin², Juan P. Wisnivesky⁴, Todd S. Weiser², Scott J. Swanson⁵, Stuart A. Aaronson³
1. Surgery, The Mount Sinai Medical Center, New York, NY, USA; 2. Cardiothoracic Surgery, The Mount Sinai Medical Center, New York, NY, USA; 3. Oncological Sciences, The Mount Sinai Medical Center, New York, NY, USA; 4. Medicine, The Mount Sinai Medical Center, New York, NY, USA; 5. Cardiothoracic Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Invited Discussant: Richard J. Battafarano, MD, PhD

F17. Development of a Navigation System for Segmentectomy Using Infrared Thoracoscopy
Noriyuki Misaki, Sung Soo Chang, Hitoshi Igai, Shintaro Tarumi, Masashi Gotoh, Hiroyasu Yokomise
General Thoracic Surgery, Breast and Endocrinological Surgery, Kagawa University, Kagawa, Japan.

Invited Discussant: Ralph A.Schmid, MD

F18. Endothelin-1 Mediates Bronchiolitis Obliterans in Lung Transplant Recipients
Mohamed Salama², Olena Andrukhova², Peter Jaksch¹, Shahrokh Taghavi¹, Walter Klepetko¹, Seyedhossien Aharinejad¹
1. Departments of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria; 2. Cardiovascular Research, Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.

Invited Discussant: Daniel Kreisel, MD, PhD

F19. Trans-lymphatic Chemotherapy Controls Lymphatic Metastasis and Prolongs Survival in an Orthotopic Lung Cancer Model
Jiang Liu¹, Ming Li¹, Michael R. Johnston²
1. Princess Margaret Hospital / University Health Network, Toronto, ON, Canada; 2. Thoracic Surgery, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, NS, Canada.

Invited Discussant: Michael Liptay, MD

F20. Profound Cytotoxicity of the Histone Deacetylase Inhibitor SAHA (Suberoylanilide Hydroxamic Acid) and TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) Combination in Malignant Pleural Mesothelioma
Javier T. Varona Santos¹, Medhi Wangpaichitr², Min You², Niramol Savaraj², Dao M. Nguyen¹
1. Division of Cardiothoracic Surgery, Department of Surgery, MiIller School of Medicine, University of Miami, Miami, FL, USA; 2. Division of Medical Oncology, Department of Medicine, VA Medical Center, University of Miami, Miami, FL, USA.

Invited Discussant: David S. Schrump, MD