科学家发现干细胞与肺癌的关系（肺癌相关信息）_支修益大夫

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科学家发现干细胞与肺癌的关系（肺癌相关信息）

(2009-05-29 01:01:00)

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杂谈

（一）Scientists discover stem cell clue to lung cancer development

Cancer Research UK scientists have revealed that stem cells become 'activated' in severely damaged lungs and help to repair them, according to a study published in the Proceeding of the National Academy of Sciences* today.

These findings provide a crucial new insight into how lungs function on a cellular level and could help scientists devise a test to detect the early stages of lung cancer in people who are at a high risk of developing damaged lungs ?such as long term smokers.

The primary role of stem cells is to maintain and repair the tissue in which they are found. But because stem cells are rare in comparison to normal cells, identifying exactly where they are and how they work has remained elusive.

A team of scientists from Cancer Research UK's Cambridge Research Institute and led by Professor Barry Stripp from Duke University Medical School in the US used a unique 'whole-lung' imaging method to examine and identify the location of stem cells in the lung tissue of mice, and determine the role they play in both healthy and damaged lungs.

（二）英国科学家最新研究显示，干细胞疗法可能会引发癌症。

科学家建议应该对干细胞进行筛选甄别以降低风险。

据《新科学家》杂志网站8日报道，英国伦敦大学学院的研究人员对取自健康组织和癌变组织的干细胞基因行为模式进行了比较，结果发现取自癌变组织的干细胞通常会像原始干细胞一样在一种固定状态下不停地复制，而不是发育为成熟的特殊组织如乳房或卵巢。

研究人员认为，这种情况似乎是“POLYCOMB”基因失去活性引起的，而“POLYCOMB”基因在癌症中通常容易在一种被称为“甲基化”的化学反应过程中被“关闭”。研究人员说，处于这种“关闭”状态的“POLYCOMB”基因经过分裂再分裂，会出现异常变异，最终转变为致癌基因。

科学家建议，在进行干细胞疗法之前，应筛选甄别干细胞，确定它们是否有甲基化现象，以剔除“危险分子”，这同时也是诊断早期癌症的一种方法。

信息来源:央视国际

（三）WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor

There are urgent needs to develop methods for early detection of nonsmall cell lung cancer (NSCLC) because of its increasing incidence and poor prognosis.

This study analyzed the production of IgG antibody (WT1 Ab) against WT1 (Wilms' tumor gene) protein that was overexpressed in the majority of NSCLC.

Enzyme-linked immuno-sorbent assay showed that WT1 Ab was produced in all of 91 NSCLC patients and 70 healthy individuals and that WT1 Ab titers were significantly higher in NSCLC patients compared with healthy individuals.

The results showed that WT1 Ab could be a useful marker for early detection of NSCLC and its prognostic prediction. These results also suggested that WT1-specific immune responses played an important role in anti-cancer immunity in NSCLC.

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