Those include：

1、肥胖/ obesity (specifically, high body mass index, an indication of obesity, in midlife);

2、颈动脉斑块形成/carotid artery disease, in which plaque buildup narrows major neck arteries and slows blood supply to the brain;

3、 高血压/high blood pressure;

4、抑郁/depression;

5、体质差/being frail;

6、文化程度偏低/being poorly educated;

7、高同型半氨酸血症/having high levels of a naturally occurring amino acid known as homocysteine;

8、吸烟/being a smoker；

9、2型糖尿病/having either type 2 diabetes.