研究提示“肾功能衰竭的患者易并发上消化道～食道、胃和十二指肠等部位出血”。进一步分析显示“肾功能衰竭接受透析的患者特别容易并发上消化道出血”。因此，临床医生必须对此有所警惕，以及时发现此类异常，并给予以相应的处理。

Kidney Failure Patients Prone to GI Tract Bleeding

Bleeding in the esophagus, stomach and intestine can be deadly for dialysis patients, study says

THURSDAY, Jan. 19 (HealthDay News) -- Many kidney failure patients experience bleeding in the upper gastrointestinal (GI) tract, a problem that can cause serious health problems and even early death, a new study shows.

The researchers said their findings show that more needs to be done to prevent and treat upper GI bleeding -- which occurs in the esophagus, stomach or first part of the intestine -- in kidney failure patients.

They noted that kidney failure patients on dialysis are particularly prone to upper GI bleeding.

For this study, the researchers examined data from nearly 1 million patients in the U.S. Renal Data System, which collects information on most of the dialysis patients in the country.

The analysis revealed that rates for upper GI bleeding were either 57 or 328 episodes per 1,000 kidney failure patients per year, according to stringent and lenient definitions of what qualifies as upper GI bleeding. That's more than 10 times higher than the general population, according to the American Society of Nephrology news release.

The study also found that nearly 12 percent of kidney failure patients who had upper GI bleeding died within a month of bleeding, but there was a significant decline in the death rate from 1998 to 2007.

The death rate fell from a little more than 12 percent in 1998 to 10.5 percent in 2007 according to the stringent definition of upper GI bleeding, and from about 10 percent to 8 percent according to the lenient definition.

Despite that decline -- which may be due to improvements in medical care -- the dangers of upper GI bleeding in kidney failure patients remain a substantial issue, said the Stanford University School of Medicine researchers and colleagues.

The study appears online Jan. 19 in the Journal of the American Society of Nephrology.

SOURCE: Journal of the American Society of Nephrology, news release, Jan. 19, 2012