最近有研究发现，2005年智利地震时怀孕或称在该地区地震时期怀孕处于前三个的孕妇早产者和生女孩者更多。通过分析大量的资料后，研究人员发现以往该地区的男孩与女孩出生比大致为51：49，但在2005年～2006年间，这一比例变更我为45：55，即男孩出生率较地震前显著较低。基于上述结果，研究人员认为妊娠早期（前三个月）孕妇的心态可以显著影响胎儿出生的性别，也即早期妊娠的孕妇焦虑心态或因故（如地震）而处于应激状态下更易生女孩和更可能发生早产。

Stress Early in Pregnancy Linked to Fewer Baby Boys

Women in first trimester during major earthquake gave birth earlier and had more girls, study finds

THURSDAY, Dec. 8 (HealthDay News) -- A stressful early pregnancy could lower a woman's odds for delivering a boy and raise her risk for premature delivery, a new study suggests.

The findings from an investigation of how the stress of a major 2005 earthquake affected pregnant women in Chile suggest that pregnancy can be impacted by exposure to stress itself rather than the factors that often accompany or cause stress, such as poverty, the researchers said.

The investigators analyzed the birth certificates of all the babies born in Chile between 2004 and 2006, which was more than 200,000 per year. The birth records provided information about the babies and their mothers, including how close the mothers lived to the epicenter of the magnitude 7.9 earthquake.

Reporting in the Dec. 8 issue of Human Reproduction, the study authors found that exposure to the earthquake during the third month of pregnancy reduced the ratio of male to female births.

"Generally, there are more male than female live births. The ratio of male to female births is approximately 51:49 -- in other words, out of every 100 births, 51 will be boys. Our findings indicate a 5.8 percent decline in this proportion, which would translate into a ratio of 45 male births per 100 births, so that there are now more female than male births. This is a significant change for this type of measure," Dr. Karine Kleinhaus, an assistant professor of psychiatry, obstetrics & gynecology, and environmental medicine at New York University, said in a journal news release.

This finding may be related to previous research, which has found that male fetuses tend to grow larger than females and need more resources from the mother, and therefore are more likely to miscarry in times of stress. In addition, male fetuses may be less robust than females and may be less capable of adapting their development to a stressful environment in the womb.

The study also revealed that women who experienced the earthquake during their second and third months of pregnancy had shorter pregnancies and were more likely to have premature babies.

Compared to women in parts of Chile unaffected by the earthquake, the pregnancies of women exposed to the earthquake in the second month of pregnancy were an average of 1.3 days shorter, and the pregnancies of those exposed to the earthquake in the third month of pregnancy were an average of about 2 days shorter, the findings showed.

More than nine in 100 women exposed to the earthquake in the third month of pregnancy had a premature baby, a 3.4 percent increase over the normal rate of about six in 100. The effect was most notable among baby girls -- close to a 4 percent increase in premature birth if the mother was exposed to the earthquake in the second month of pregnancy and a 3.8 percent increase if it occurred in the third month.

Earthquake exposure had no statistically significant effect on the risk of having a premature baby boy, the researchers noted.

SOURCE: Human Reproduction, news release, Dec. 7, 2011