观察表明，约有1/4的慢性肾病患者在接受透析治疗过程中出现低血压，而这种于透析过程中出现的低血压（Low blood pressure while undergoing dialysis）可增加患者与透析机连接处之血管内的血栓形成。这是否可以解释以往所见的某些接受透析治疗的慢性肾病患者可伴有胃肠不适、神经肌肉症状，甚至出现中风、心肌损害和死亡呢？大家想想！

Blood Pressure Drop During Dialysis May Raise Clot Risk

Low BP occurs in about 25% of these treatment sessions in kidney-failure patients, researchers say

FRIDAY, July 29 (HealthDay News) -- Low blood pressure while undergoing dialysis puts patients at increased risk for clots where their blood vessels are connected to the dialysis machine, a new study says.

Previous research had found that a sudden drop in blood pressure during dialysis can lead to short-term gastrointestinal, muscular and neurologic symptoms, and long-term problems such as stroke, seizure, heart damage and death.

This new study, led by researchers at Stanford University School of Medicine, examined data collected between 1995 and 2000 from 1,426 dialysis patients who took part in a clinical trial sponsored by the U.S. National Institutes of Health.

Dialysis is a treatment for kidney-failure patients that uses a machine to cleanse their blood. Many patients are attached to the dialysis machine through a fistula, a surgically created vascular access point in the body that's connected to the tubes that take and return blood to the dialysis machine.

The analysis revealed that patients who experienced low blood pressure most often while undergoing dialysis were two times more likely to have a clotted fistula than those who had the fewest episodes of low blood pressure.

"Our analysis shows another adverse consequence associated with a fall in blood pressure during dialysis for patients," lead author and nephrologist Dr. Tara Chang said in a Stanford news release. "Vascular access is their lifeline. It's required for dialysis and without dialysis, they'll die."

Because low blood pressure occurs in about one-quarter of dialysis sessions, "physicians already try to avoid low blood pressure during dialysis through various means," Chang said. "This is just one more good reason to continue these efforts."

The study is published in the July 29 online edition of the Journal of the American Society of Nephrology.

SOURCE: Stanford University, news release, July 29, 2011