日前，美国妇产科医师协会（the American College of Obstetricians and Gynecologists ，ACOG)声称，经查阅相关资料，该协会认为呋喃西林（nitrofurans）和磺胺类药物（sulfonamides）并不增加新生儿出生缺陷的发生率，或者说这两类抗菌素与新生儿出生缺陷之发生无关，也即在没有其它更好选择的前提下，这两类药物仍可用于孕妇，以治疗泌尿系统等处感染。

Certain Antibiotics During Pregnancy May Be Safe After All

Ob/gyn group says they're OK for treating urinary tract infections if no other alternative

MONDAY, May 23 (HealthDay News) -- Two antibiotics that were linked to birth defects may be safe to take during pregnancy after all, an obsetricians/gynecologists group says.

The antibiotics, nitrofurans and sulfonamides, are typically used to treat urinary tract infections, at least until a 2009 report found that the antibiotics may increase the risk for birth defects if taken during the first trimester of pregnancy.

But after reviewing the existing research, the American College of Obstetricians and Gynecologists (ACOG) determined that the antibiotics are still "appropriate when there is no suitable alternative," according to an ACOG news release.

The 2009 study that raised alarm about the antibiotics had significant limitations, including that it relied on women's recall of what they'd taken during pregnancy. In addition, subsequent studies found no link between nitrofurans and sulfonamides and birth defects.

"Antibiotics are commonly prescribed during pregnancy for a variety of bacterial infections, so there is considerable data now on the relationship of antibiotic exposure to birth defects," said Dr. William H. Barth, Jr., chair of ACOG's Committee on Obstetric Practice, in a news release.

The 2009 study "had several significant limitations, including patient recall bias. Furthermore, this was an observational study, so it's impossible to know whether 　　the birth defects were caused by the antibiotic or the infection itself, or some other factor," he added.

ACOG's Committee Opinion was published in the June issue of Obstetrics & Gynecology.

SOURCE: The American College of Obstetricians and Gynecologists, news release, May 23, 2011