很久以来，人们一向认为巴金森氏病因环境因素所致，但自从2007年科学家们发现六个基因变异可影响人们患巴金森氏病之风险后，学术届对该病之发生机理改变了原有的看法。

　　日前发表在柳叶刀杂志（The Lancet）的文章再一次表明，另有五个基因变异与巴金森氏病的发病有关。研究人员分析发现，具有上述十一个变异基因的个体发生该病的风险显著高于那些少有上述基因变异的个性（注：两组被试者的发病风险相差2.5倍之多）。

　　（更多资讯：请参阅下文）。

　　WEDNESDAY, Feb. 2 (HealthDay News) -- Five new genetic variants believed to play a role in Parkinsons disease have been identified by researchers.

　　It was long believed that Parkinsons disease was caused by environmental factors. But since 2007, scientists have pinpointed six genetic variants that may affect a person risk of developing the condition. This new study brings that to a total of 11 genetic variants.

　　Andrew Singleton, of the National Institute on Aging at the U.S. National Institutes of Health in Bethesda, Md., and an international team of scientists conducted a meta-analysis of five genome-wide association studies that were conducted in Europe and the United States and covered about 7.7 million possible genetic variants.

　　The analysis showed that 20 percent of people with the highest number of the 11 identified gene variants were 2.5 times more likely to develop Parkinsons disease than the 20 percent of people with the least number of genetic risk factors.

　　The new findings are a starting point for further research into how Parkinsons disease develops, said the researchers.

　　"The identification of additional common and rare risk variants for Parkinsons disease will probably revise our estimate of the genetic component of [the] disease upward," they concluded in their report.

　　The study was released online Feb. 2 in advance of publication in an upcoming print issue of

The Lancet.

　　SOURCE: The Lancet, news release, Feb. 1, 2011