加载中…研究表明维生素E是防治皮肤光照损伤的利器
(2012-03-12 15:00:14)
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意大利科学家研究发现使用含有维生素E的一款局部护理配方产品可以有效减少光照对皮肤的损伤。
众所周知，维生素A因其对紫外辐射的吸收作用而广泛应用于皮肤学中，然而现在的研究发现一款富含维生素E化合物生育三烯酚和生育酚的局部护理配方对防治皮肤光照损伤具有良好的效果。
研究发现：“ 维生素E配方产品预处理皮肤后，对皮肤抵抗光敏感性具有高度保护作用，同时，与一般样品和含维生素A样品涂抹的皮肤相比，含维生素E配方产品涂抹的皮肤对辐射产生的所有反应都有明显的较低作用。”
生育三烯酚和生育酚
使用含有一定浓度生育三烯酚和生育酚的局部护理配方是减少光照皮肤损伤的有力武器。
这个发现被刊登在欧洲高等学院皮肤病与性病杂志上，同时阐明生育三烯酚作为维生素E家族的一员，与生育酚相比拥有超级活性，这使得维生素E具有更广阔的应用。
在此之前生育三烯酚的研究非常之少，但是新的研究表明生育三烯酚可以应用于部分防晒霜，保湿剂和其他的皮肤护理产品中。
光敏感性测试
为了实验证明这种抗氧化剂的光保护性能，米兰大学的研究者挑选出130位的光敏感患者，最终结果显示：与一般样品和含维生素A样品涂抹的皮肤区域相比，含有10%生育酚和0.3%生育三烯酚的新外用试剂对皮肤具有明显的预防功效。
在测试最小UVB红斑计量（MED）后，在每个主体的屁股上选出两块4平方厘米的区域，一块涂抹抗氧化配方而另一块不做任何处理。然后两块区域都被照射两倍的MED。后续又挑选15位患者对其手臂前臂选择类似的两块区域进行测试，光照辐射量相同。光照反应通过分配分数指示的强度进行评估。
Study suggests vitamin E is the answer to reducing photo-induced skin damage
By Andrew McDougall+, 24-Jan-2012
Related topics: Anti-ageing, Formulation & Science, Skin Care
Italian scientists have found that the use of a new topical formulation containing vitamin E is effective and shows promise in reducing photo-induced damage.
Vitamin A is well-known in dermatology for its actions, including the ultraviolet radiation absorbing property, however the new study suggests that a topical formulation containing the vitamin E compounds tocotrienols and tocopherols, could be more effective.
“The pre-treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A,” notes the study.
Tocotrienols and tocopherols
“The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo-induced skin damage.”
The findings, published in the Journal of the European Academy of Dermatology and Venereology, also suggest that tocotrienols, part of the vitamin E family, have superior activity to tocopherols, a more widely used vitamin E compound.
Tocotrienols have been sparsely studied up until recently, but the new research suggests there may be a use for them particularly in sunscreen, moisturisers and other skin care products.
Photosensitivity testing
In view of experimental evidence for the photoprotective properties of these antioxidants, the researchers, from the University of Milan, evaluated i30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10 per cent and tocotrienols 0.3 per cent, compared with retinol, simple vehicle and untreated areas.
After determination of the minimal UVB erythema dose (MED), two areas of 2×2cm were selected on the rear end of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Both areas were then irradiated with a twofold MED.
As further controls, two similar areas, selected on the forearm of 15 patients, were photo-irradiated similarly.
An assessment of the reactions was then carried out assigning scores indicative of their intensity.
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Study suggests vitamin E is the answer to reducing photo-induced skin damage
Italian scientists have found that the use of a new topical formulation containing vitamin E is effective and shows promise in reducing photo-induced damage.
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