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我们知道acrobat等软件可以对pdf文件进行处理，比如加注释，删除文字等，这里我们看看如何用latex来实现添加注释如下图便是演示效果：

首先，我们可以使用cooltooltips来实现，代码如下：

\documentclass{article}

\usepackage{cooltooltips}
\usepackage{graphicx}
\usepackage{color}
\usepackage{hyperref}

\def\cool{\texttt{cool}}
\begin{document}

The \cool\ package enables a document to contain hyperlinks that pop
up a brief tooltip when the mouse moves over them and also open a
small window containing additional text.  \cool\ works only with
pdf\LaTeX\@.  Furthermore, the tooltips that \cool\ produces are much
less cool when viewed under older versions of Acrobat~($<7.0$) or the
current version of xpdf~(3.00) because they don't pop up the extra,
small window.
\cooltooltip[0 0 1]{Example}{This is an example of a cool tooltip.
Pretty cool, eh?}{http://www.ctan.org/}{Visit CTAN on the Web}{This text\strut}
%
is an example of a cool tooltip (assuming
you're viewing this document with a sufficiently capable \textsc{pdf}
reader).  Move your mouse pointer over it and watch what happens.
Then, click on the link.  If your \textsc{pdf} reader is properly
configured it should launch a Web browser and send it to the
\textsc{ctan} home page.

\end{document}

选自：http://tex.stackexchange.com/questions/9796/how-to-add-todo-notes

其次，更为全面的功能，比如添加附件，注释样式多样等等可以使用pdfcomment宏包来实现：

http://www.ctan.org/tex-archive/macros/latex/contrib/pdfcomment

演示图：