Name: Cyclosporin A/环孢素A/环孢菌素A

Synonym: cyclosporine; Ciclosporin; Cyclosporine A; Cyclosporin; Sandimmune;

Cas No: 59865-13-3

MF: C62H111N11O12

Molecular:1202.61

Sequence:Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl), BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA

从土壤真菌提取物中提取的环状十一肽。它是一种对T淋巴细胞有特异作用的强大免疫抑制剂。A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation.

环孢菌素是由某些丝孢纲(Hyphomycetes) 真菌如光泽柱孢菌(Cylindrocarpon lucidum)和膨大弯颈霉(Tolypocladium inflatum)的培养液中分离出的一种亲脂性环状多肽化合物，20世纪80年代作为免疫抑制剂已在世界范围内被广泛应用。 环孢菌素一种很强的免疫抑制剂，可抑制细胞介质的反应发作，能可逆性抑制T细胞增殖，不抑制血细胞的生成，也不影响吞噬细胞功能，具有较少诱发或加重感染的优点。