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关于男病友服药期间生小孩

(2010-07-25 16:03:00)
标签:

白血病

怀孕

格列卫

生小孩

健康

分类: 资讯搜集

男病友服药期间生小孩问题,确切的来说,目前还没有一个权威的准确的说法。在08年我也写过一篇这方面的博文,当时的问题也是现在的问题:“未知的问题是:男性慢粒,如果女方怀孕,影响情况如何?与服药时间长短有多大关系?是否服药时间越长,影响越大?”

 

最近再去查国外的资料,查到的结果大多都是男病友吃药期间生小孩似乎问题不大,理论上对sperm有些数量和活动性上的影响,但对生殖的影响不大。缺少的就是一份系统性的研究报告,比如发表在《BLOOD》这种权威性期刊上的论文。但也没有发现任何关于确定格列卫会对男性生殖产生必然影响的论文。

 

下面是我在美国白血病与淋巴瘤协会LLS的论坛上的帖子,有几位国外病友的答复和一些文章的链接。Trey是个比较专业的病友,09年以来已经发过1000多个帖子了,记得这个论坛改版前他就一直很活跃,找来的链接都比较让人信服。当然,这些都只是参考。最重要的是要询问自己的主治大夫,因为因人而异,每个人的情况不一样的,是有个体差异的,主治大夫应该是最了解具体情况的人了。

 

http://community.lls.org/message/63654

 

Tang  

3 发贴自
2010/07/19

当前正在审批

2010/07/19 23:15

Male patient want baby, Any reliable Paper?

I'm Tang from Beijing. MALE. dxd with CML CP on the Christmas day of 2007, with PCR  74.9%. taken 400mg Glivec from Jan. 9th, 2008. and now, MMR, the PCR of the peripheral blood test got ZERO.

 

From this April, I had get off the Glivec till last week. In this three months, I tried to make a baby, but I didn't have a good luck, maybe I missed my wife's accurate ovulation time. Before stopping Glivec, I took a sperm test, and it's ok.

 

so, I wonder whether I can make baby when I take Glivec. is there some reliable paper on the authoritative journal? Thanks!

 

And I googled the following sentence, is this believable?

 

http://www.fertilehope.org/learn-more/cancer-and-fertility-info/fertility-risks-men.cfm

 

  • Gleevec® (imatinib)
    There seems to be no effect to male fertility from Gleevec, and it appears to be safe to father a child while you are taking Gleevec.
标签: baby, cml
Tang   3 发贴自
2010/07/19
当前正在审批
1. 2010/07/19 23:20 回复: Tang
Re: Male patient want baby, Any reliable Paper?

I'm 28.

Anyone successfully makes healthy baby with your wife when you take glivec?

garycris   64 发贴自
2010/06/23
当前正在审批
2. 2010/07/20 15:13 回复: Tang
Re: Male patient want baby, Any reliable Paper?

Hi Tang

 

I'm not sure if you have seen these links but hopefully they will assist you

 

http://jco.ascopubs.org/cgi/content/full/24/7/1204

http://www.cmlsupport.org.uk/node/5251

http://www.fertilehope.org/learn-more/cancer-and-fertility-info/tyrosine-kinase-inhibitors.cfm

http://www.cmlsupport.org.uk/node/6567

http://community.lls.org/message/52770;jsessionid=78340699C8CFF25743D877223880A29D

http://www.oncolink.org/experts/article.cfm?c=2&s=7&ss=14&id=2554

 

Overall the concensus seems to be that Gleevec for the father not an issue, Gleevec for the mother, likely an issue.  They note some reduction of sperm count and motility.  You said you took a sperm test, but not sure what they looked at.  You may want to visit with a fertility specialist to do a few more tests.  I can tell you that it is not unsual to try for three months and not get pregnant.  Many people try for a lot longer before they are successful.  Stress can be a factor, so if you felt rushed to get pregnant right away before you went back on your med, that could affect both you and your wife and hamper your efforts.  If you want to continue trying you will have to make a choice to either stay off your med or go back on and continue to try.  From what I have read it does not appear to be an issue if you impregnate your wife while you are on Gleevec, but I can certainly understand your concern.

 

Best of luck to you....

Trey   1,027 发贴自
2009/03/27
当前正在审批
3. 2010/07/20 16:32 回复: Tang
Re: Male patient want baby, Any reliable Paper?

Gleevec has 10 years of history, and many men have fathered children while taking it.  There is no clear evidence that fathering a baby while taking Gleevec is unsafe.  There is no warning from Novartis for  men regarding conceiving a baby while taking Gleevec; the only warning is for women:

 

http://www.gleevec.com/patient/safety-information.jsp

 

Generally,  Gleevec and most drugs do not have access into  certain protected areas  of the body, including the brain, eye, and  testicles (just into the  blood vessels that may be in those areas).  I have never seen any  credible information warning men to avoid fathering children while  taking Gleevec.  A person can always find non-credible information about  any subject.  Many men have fathered healthy children while taking  Gleevec.

Berkalvee   7 发贴自
2009/04/20
当前正在审批
4. 2010/07/21 23:06 回复: Tang
Re: Male patient want baby, Any reliable Paper?

Tang, I am 33, diagnosed with CML at age 30, and awaiting my first child that was conceived while I was taking (and continue to take) 400 mg. of Gleevec daily.  My girlfriend is almost 31 weeks pregnant and so far the baby seems to be well developed and healthy.  It is safe to say that Gleevec wont prevent you from conceiving a baby, and I hope (and assume from what I have heard from other proud fathers of "Gleevec Babies") that it won't harm development before and after they are born either.  I hope that what I have told you helps.  I, like you, searched far and wide and I just couldn't find any real information saying that men had to worry about Gleevec interfering with the conception of a child.  Good luck and enjoy the whole "baby making" process if you decide to go through with it!  Berkley

Tang   3 发贴自
2010/07/19
当前正在审批
5. 2010/07/24 12:35 回复: Tang
Re: Male patient want baby, Any reliable Paper?

Hi, garycris, Trey, Berkalvee, Thanks a lot!

 

Your replies relieve me very much. I think I will keep on taking Gleevec, even if in the try.

 

There are many follow-ups and researches about female pregnancy while taking Gleevec on the jornal such as BLOOD, but rare about male's. If there are, I will appreciate so much who puts them here the urls.

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