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防止白血病复发的疫苗将首次人体试验

(2010-01-18 12:53:13)
标签:

白血病

疫苗

分类: 资讯搜集

最近看到两篇关于白血病疫苗的消息。不一定立竿见影马上看到实效解决一切问题,但感觉步子又往前迈了一步。

 

这是一篇1月5号的新华社的编译报道。

http://news.xinhuanet.com/world/2010-01/06/content_12763671.htm

英国正在研制防止白血病复发疫苗 
 
    新华网伦敦1月5日电(记者黄堃)英国伦敦大学国王学院5日发表公报说,该校研究人员正在研制一种防止白血病复发的疫苗,目前已进入临床试验阶段。

    据研究人员介绍,目前白血病治疗主要分两步,首先用化学疗法杀灭癌细胞,再通过持续的化学疗法或骨髓移植来防止复发。然而许多患者难以找到匹配的骨髓进行移植,因此开发出可避免复发的疫苗,对那些难以找到匹配骨髓的白血病患者来说将是好消息。

    公报说,这一疫苗的研发经历了约20年时间,其基本原理与其他疫苗一样,也是刺激人体免疫系统攻击病原细胞。研究人员从白血病患者的血液中取出一些细胞并为其植入两个基因,作为吸引免疫系统攻击的“标靶”。初步实验显示,这种方法可有效引导动物免疫系统攻击那些可导致白血病复发的病原细胞。在下一阶段的临床试验中,国王学院的科研人员将首先为接受过化疗的白血病患者试种上述疫苗。

    领导这项研究的法尔扎内教授说,这一疫苗的治疗原理还有望用于治疗若干种癌症。

 

这是英国伦敦大学国王学院官方网站上的文章链接。全文还是请看他们的官方新闻稿,里面有不少详细信息。

http://www.kcl.ac.uk/news/news_details.php?news_id=1257&year=2010

Leukaemia vaccine being developed

05 Jan 2010, PR 03/10

White Blood CellScientists at King’s have developed a vaccine treatment for Leukaemia that can be used to stop the disease returning after chemotherapy or bone marrow transplant. The vaccine is due to be tested on patients for the first time. Eventually it is hoped the drug, which activates the body's own immune system against the leukaemia, could be used to treat other types of cancers.

 

大意是:英国伦敦大学国王学院的科学家们研发出一种白血病疫苗,这种疫苗可以阻止白血病在化疗或骨髓移植后复发。该疫苗即将在病人身上进行首次试验。科学家们最终希望这种疫苗能激活人体自身的免疫系统来抵抗白血病,而且能同样的用于其它类型的癌症。 

 

The first patients to be treated as part of the clinical trial at King’s College Hospital, have the form of the disease known as Acute myeloid leukaemia (AML), the most common form in adults. Even with aggressive treatment half would usually find the disease returns. In the initial stages of the trial patients will be enrolled in the trial if they have had chemotherapy and a bone marrow transplant. If early trials are successful the vaccine may be tested in patients who cannot have a bone marrow transplant because they are unsuitable or a match cannot be found.

大意:首批参加试验的患者为急性髓系白血病(如急粒)。急性髓系白血病在成人中最常见,即使用最强的治疗,也有一半人会复发。在试验的最初阶段,会招募那些进行过化疗或骨髓移植的患者。如果初始阶段的试验取得成功的话,接下来将在因配型不成功或身体不适而不能做骨髓移植的患者中进行。

 

The idea behind cancer 'vaccines’ is not necessarily to prevent the disease. Instead, once a patient has been diagnosed, the 'vaccine' programmes the immune system to hunt down cancer cells and destroy them. The vaccine then prompts the immune system to recognise leukaemia cells if they return which prevents a relapse of the disease. The vaccine is created by removing cells from the patient's blood and manipulating them in the laboratory.

大意:这里的“疫苗”并非普通意义中的防止癌症,而是一旦患者确诊,该“疫苗”就会启动体内的免疫系统来抓获癌细胞并将其破坏,然后促使免疫系统辨认出白血病细胞来防止复发。该疫苗提取自患者的血液,并在实验室中复制而成。


The cells are given two genes which act as flags to help identify the leukaemia. It effectively focuses and boosts the immune system's ability to seek out and destroy cancer cells. The research is due to be published in the Journal of Cancer Immunology, Immunotherapy shortly.

大意:疫苗里的细胞被赋予了两个基因,他们就像风向标一样帮助辨认出白血病,同时提升体内免疫系统抓捕和破坏癌细胞的能力。该研究成果将很快被发表在《Journal of Cancer Immunology, Immunotherapy》杂志上。

相关的报道:

英国《每日电讯报》http://www.telegraph.co.uk/health/healthnews/6872451/Leukaemia-vaccine-being-developed.html

Leukaemia vaccine being developed
A vaccine for leukaemia is about to be tested on human patients for the first time, in a breakthrough which could offer hope to thousands.  
By Rebecca Smith, Medical Editor
Published: 7:00AM GMT 04 Jan 2010

美国哥伦比亚广播公司:http://www.cbsnews.com/stories/2010/01/04/health/main6053078.shtml

LONDON, Jan. 4, 2010
Human Trial for Leukemia Vaccine
U.K. Doctors Develop Treatment to Halt Disease, Boost Survival After Chemotherapy or Bone Marrow Transplant

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