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从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

(2010-01-01 01:29:53)
标签:

猴头菇

老年痴呆症

静冈大学

河岸洋和

福冈大学

藤野和隆

杂谈

分类: 科学教育

猴头菇能为老年痴呆症作什么?

——第五届国际药用菌物大会论坛专题报道

发布: 2009-09-22 作者: 鹏南(流云似水的笔名)

日本学者“从猴头菇中分离一种具有抗痴呆症作用的弱极性组分”

 

  2009年9月5-8日,在中国江苏省南通市举办的第五届国际药用菌物大会论坛上——

  针对猴头菇的药理研究,有了世纪性的突破。

 

  日本静冈大学河岸洋和教授,在论坛作《从猴头菇中分离一种具有抗痴呆症作用的弱极性组分》  ( 《Anti-dementia effects of a low polarity fraction extracted from Hericium erinaceum》)的学术报告。

  引起与会众多学者对猴头菇药理研发的关注。

 

从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

 图一 日本静冈大学河岸洋和教授在大会论坛上作《猴头菇与老年痴呆症》报告

 

从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

图二 从猴头菇中分离出的有效物质

  从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

图三 猴头菇中分离出有效物质的分子式

 

从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

 图四 使用猴头菇对阿尔茨海默氏症进行临床测试的医疗机构

 

从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

图五 河岸洋和教授提供的临床试验报告数据

 

    2002年,河岸洋和教授和其它三名学者在美国《探索( <Exploer> )》杂志上——发表了一篇有关猴头菇可以作为预防或治疗阿尔茨海默氏症(Alzheimer)的食物或药物来进行开发的研究论文(见相关链接)。

 

    由此,猴头菇——作为预防-治疗阿尔茨海默氏症(Alzheimer)的食物-药物的药理-临床研究——

  开始被国际医学界关注。

 

从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

图六 韩国玛西蒙总经理(左一)、日本静冈大学教授河岸洋和(中)和玛西蒙总裁在玛西蒙展位前合影留念

 

 

[ 相关报道 ]

 The Inducer of the Synthesis of Nerve Growth Factor From Lion's Mane (Hericium erinaceus)

© Copyright 2002 by Hirokazu Kawagishi,1 Ph.D., Shoei Furukawa,2 Ph.D., Cun Zhuang,3 Ph.D., and Rika Yunoki 4; Japan & USA
(Explore Issue: Volume 11, Number 4)

Abstract

Nerve growth factor (NGF) is closely related to Alzheimer's dementia, and studies have suggested that the disease may be prevented or its symptoms may be improved when NGF is given into the brain directly. However, since NGF is a protein it usually cannot pass through the blood-brain barrier. Recently, researchers have targeted on the substances that could pass through the blood-brain barrier and induce NGF synthesis in the brain. Some compounds with lower molecular weight have been found to have such bioactivity. Among these bioactive compounds, hericenones and erinacines, which were isolated from an edible mushroom called as Lion's Mane (Hericium erinaceus), showed remarkable activity of stimulating the synthesis of NGF. They could be developed as a dietary supplement or medicine to be used for treating Alzheimer's dementia. This article offers an introduction to the isolation method, bioactivity assay and chemical structure analysis of hericenones and erinacines.

The Anti-Dementia effect of Lion's Mane mushroom and its clinical application - Hericium erinaceum - Lion's Mane

Townsend Letter for Doctors and Patients, April, 2004 by Hirokazu Kawagishi, Cun Zhuang, Ellen Shnidman

Introduction

Medicinal Mushrooms have become a hot item in the mass media in the last few years but the information being disseminated about them is not always scientifically accurate. Most of the studies on the efficacy of medicinal mushrooms that are available to the public are based on animal studies (usually in mice) or cultured cells. In these cases, the bioactivity of the mushroom extracts cannot always be correlated to their activity when ingested by humans--either orally or by injection.

Our research on components of Lion's Mane mushroom (Hericium erinaceum) and their biological activities in cell culture is a case where positive antidementia results in the laboratory have been confirmed by analogous results in human use. In this article, we will introduce both the results from the laboratory and their clinical application.

Conventional Treatments of Alzheimer's Disease

 

从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

   图七  日本福冈大学“猴头菇-老年痴呆症药理-临床研究”示图

 

 从猴头菇中分离一种具有抗痴呆症作用的弱极性组分

 

图八  图七作者之一的藤野和隆先生(左)于2009年11月22日访问北京玛西蒙科技有限公司

  • 北京玛西蒙科技有限公司总裁(中)、
  • 玛西蒙韩国总代理商金斗璟先生(右)

 

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